Practical laboratory considerations amidst the COVID-19 outbreak: early experience from Singapore.
Identifieur interne : 000475 ( Main/Exploration ); précédent : 000474; suivant : 000476Practical laboratory considerations amidst the COVID-19 outbreak: early experience from Singapore.
Auteurs : Shaun S. Tan [Singapour] ; Benedict Yan [Singapour] ; Sharon Saw [Singapour] ; Chun Kiat Lee [Singapour] ; Ai Teng Chong [Singapour] ; Roland Jureen [Singapour] ; Sunil Sethi [Singapour]Source :
- Journal of clinical pathology [ 1472-4146 ] ; 2020.
Abstract
The coronavirus disease 2019 (COVID-19) is a zoonotic viral infection originating from Wuhan, China in December 2019. The World Health Organization has classified this pandemic as a global health emergency due to its virulent nature of transmission, which may lead to acute respiratory distress syndrome. Singapore's health ministry has responded with enhanced surveillance of COVID-19 for all suspected pneumonia cases, further increasing the volume of testing via real-time reverse transcription PCR, as well as samples necessitating stringent infectious control. Collectively, this has implications on the total testing process, laboratory operations and its personnel due to biosafety concerns. Turnaround time for routine testing may also be affected. The aim of this article is to present our tertiary institution's early experience with managing this emerging crisis and offer practical considerations for the preanalytical, analytical and postanalytical phases of laboratory testing in this cohort of patients.
DOI: 10.1136/jclinpath-2020-206563
PubMed: 32198190
Affiliations:
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Tan</name><affiliation wicri:level="1"><nlm:affiliation>National University Hospital, Singapore shaun_sy_tan@nuhs.edu.sg.</nlm:affiliation><country wicri:rule="url">Singapour</country><wicri:regionArea>National University Hospital</wicri:regionArea></affiliation></author><author><name sortKey="Yan, Benedict" sort="Yan, Benedict" uniqKey="Yan B" first="Benedict" last="Yan">Benedict Yan</name><affiliation wicri:level="1"><nlm:affiliation>National University Hospital, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>National University Hospital</wicri:regionArea></affiliation></author><author><name sortKey="Saw, Sharon" sort="Saw, Sharon" uniqKey="Saw S" first="Sharon" last="Saw">Sharon Saw</name><affiliation wicri:level="1"><nlm:affiliation>National University Hospital, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>National University Hospital</wicri:regionArea></affiliation></author><author><name sortKey="Lee, Chun Kiat" sort="Lee, Chun Kiat" uniqKey="Lee C" first="Chun Kiat" last="Lee">Chun Kiat Lee</name><affiliation wicri:level="1"><nlm:affiliation>National University Hospital, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>National University Hospital</wicri:regionArea></affiliation></author><author><name sortKey="Chong, Ai Teng" sort="Chong, Ai Teng" uniqKey="Chong A" first="Ai Teng" last="Chong">Ai Teng Chong</name><affiliation wicri:level="1"><nlm:affiliation>National University Hospital, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>National University Hospital</wicri:regionArea></affiliation></author><author><name sortKey="Jureen, Roland" sort="Jureen, Roland" uniqKey="Jureen R" first="Roland" last="Jureen">Roland Jureen</name><affiliation wicri:level="1"><nlm:affiliation>National University Hospital, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>National University Hospital</wicri:regionArea></affiliation></author><author><name sortKey="Sethi, Sunil" sort="Sethi, Sunil" uniqKey="Sethi S" first="Sunil" last="Sethi">Sunil Sethi</name><affiliation wicri:level="1"><nlm:affiliation>National University Hospital, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>National University Hospital</wicri:regionArea></affiliation></author></analytic><series><title level="j">Journal of clinical pathology</title><idno type="eISSN">1472-4146</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The coronavirus disease 2019 (COVID-19) is a zoonotic viral infection originating from Wuhan, China in December 2019. The World Health Organization has classified this pandemic as a global health emergency due to its virulent nature of transmission, which may lead to acute respiratory distress syndrome. Singapore's health ministry has responded with enhanced surveillance of COVID-19 for all suspected pneumonia cases, further increasing the volume of testing via real-time reverse transcription PCR, as well as samples necessitating stringent infectious control. Collectively, this has implications on the total testing process, laboratory operations and its personnel due to biosafety concerns. Turnaround time for routine testing may also be affected. The aim of this article is to present our tertiary institution's early experience with managing this emerging crisis and offer practical considerations for the preanalytical, analytical and postanalytical phases of laboratory testing in this cohort of patients.</div></front></TEI><affiliations><list><country><li>Singapour</li></country></list><tree><country name="Singapour"><noRegion><name sortKey="Tan, Shaun S" sort="Tan, Shaun S" uniqKey="Tan S" first="Shaun S" last="Tan">Shaun S. Tan</name></noRegion><name sortKey="Chong, Ai Teng" sort="Chong, Ai Teng" uniqKey="Chong A" first="Ai Teng" last="Chong">Ai Teng Chong</name><name sortKey="Jureen, Roland" sort="Jureen, Roland" uniqKey="Jureen R" first="Roland" last="Jureen">Roland Jureen</name><name sortKey="Lee, Chun Kiat" sort="Lee, Chun Kiat" uniqKey="Lee C" first="Chun Kiat" last="Lee">Chun Kiat Lee</name><name sortKey="Saw, Sharon" sort="Saw, Sharon" uniqKey="Saw S" first="Sharon" last="Saw">Sharon Saw</name><name sortKey="Sethi, Sunil" sort="Sethi, Sunil" uniqKey="Sethi S" first="Sunil" last="Sethi">Sunil Sethi</name><name sortKey="Yan, Benedict" sort="Yan, Benedict" uniqKey="Yan B" first="Benedict" last="Yan">Benedict Yan</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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